منابع مشابه
ACE polymorphisms.
Angiotensin converting enzyme (ACE) plays an essential role in two physiological systems, one leading to the production of angiotensin II and the other to the degradation of bradykinin. The wide distribution and multifunctional properties of these peptides suggest that ACE could be involved in various pathophysiological conditions. The discovery that ACE levels are under genetic control ushered...
متن کاملAssociation studies, ACE polymorphisms and renal disease.
The genetic contribution to major disorders is increasingly recognized. This usually reflects interaction at a number of different loci to determine the eventual clinical phenotype, and dissecting out the role of individual components is a complex task. However, a clear understanding of the genetic factors involved in diseases such as hypertension, atherosclerosis, diabetes and glomerulonephrit...
متن کاملGene polymorphisms of ACE and the angiotensin receptor AT2R1 influence serum ACE levels in sarcoidosis.
Angiotensin converting enzyme (ACE) is thought to influence susceptibility, disease progression, and/or outcome of sarcoidosis by functional mutations/polymorphisms of the ACE gene, such as the ACE gene deletion/insertion (D/I) polymorphism or the angiotensin receptors like the angiotensin II receptor type 1 (AT2R1) A1166 --> C polymorphism. The aim of our study was to examine the distribution ...
متن کاملACE and MTHFR gene polymorphisms in unexplained recurrent pregnancy loss.
AIM To assess the association between polymorphisms in angiotensin converting enzyme and methylene tetrahydrofolate reductase genes and recurrent pregnancy loss by a case-control study in South Indian women. METHODS DNA was extracted from peripheral blood leukocytes of 104 women with Recurrent Pregnancy Loss (RPL) and 120 controls. Genotyping of ACE Insertion Deletion and MTHFR C677T polymorp...
متن کاملAssociation of ACE polymorphisms with left ventricular hypertrophy.
The angiotensin converting enzyme gene (ACE) is a candidate gene for an individual's genetic susceptibility to left ventricular hypertrophy (LVH). LVH has long been thought to be an end point of essential hypertension (EH), rather than a separate entity, though it is influenced by a unique set of hormonal, vascular and genetic factors. In this study, we attempted to determine whether two repres...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2006
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.0000223145.74217.e7